2017 Major Employers of Lethbridge - Lethbridge Companies Employing 100 or More People
| Employer | Business Activity | Staff |
| Alberta Health Services | Health Care & Social Assistance | 3,368 |
| University of Lethbridge | Educational Services | 2,431 |
| Lethbridge School District Number 51 | Educational Services | 1,500 |
| City of Lethbridge | Public Administration | 1,462 |
| Lethbridge College | Educational Services | 955 |
| Alberta Government | Public Administration | 900 |
| Holy Spirit Catholic Schools Division #4 | Educational Services | 779 |
| Sunrise Poultry | Food Manufacturing | 625 |
| Covenant Health | Health Care & Social Assistance | 603 |
| Palliser Regional Schools | Educational Services | 519 |
| Lethbridge Research Centre | Professional, Scientific & Technical Services | 443 |
| Maple Leaf Foods Inc. - Lethbridge Pork | Food Manufacturing | 425 |
| PepsiCo Foods Canada | Food Manufacturing | 400 |
| McDonalds | Accommodation & Food Services | 400 |
| Lethbridge Family Services | Health Care & Social Assistance | 375 |
| Green Acres Foundation | Health Care & Social Assistance | 341 |
| Sobeys | Retail | 338 |
| Triple M Housing | Manufacturing | 325 |
| Costco | Retail | 285 |
| Save-On Foods | Retail | 267 |
| Charlton & Hill | Manufacturing | 265 |
| Kawneer | Manufacturing | 257 |
| CP Rail | Transportation & Warehousing | 250 |
| Real Canadian Superstore | Retail | 225 |
| Southern Alberta Community Living Association | Health Care & Social Assistance | 222 |
| McCain | Food Manufacturing | 217 |
| Shoppers Drug Mart | Retail | 212 |
| Davis Auto Group | Retail | 211 |
| Canadian Tire | Retail | 189 |
| Cavendish Farms | Food Manufacturing | 185 |
| Western Tractor | Retail | 163 |
| Richardson Oilseed | Food Manufacturing | 160 |
| Casino Lethbridge | Arts, Entertainment & Recreation | 155 |
| ATB Financial | Finance & Insurance | 153 |
| H&R Transport | Transportation & Warehousing | 143 |
| Meridian Manufacturing | Manufacturing | 142 |
| Pratt & Whitney | Manufacturing | 141 |
| SRI Homes | Manufacturing | 139 |
| Southland Trailer Corp | Manufacturing | 131 |
| Lethbridge Iron Works | Manufacturing | 130 |
| Haul-All Equipment | Manufacturing | 130 |
| Home Depot | Retail | 125 |
| Browns Social House | Accommodation & Food Services | 124 |
| MNP | Professional, Scientific & Technical Services | 124 |
| RBC | Finance & Insurance | 120 |
| KB Heating & Air Conditioning | Construction | 109 |
| Varsteel | Manufacturing | 105 |
| Lethbridge County | Public Administration | 104 |
| Firestore Restaurant & Bar | Accommodation & Food Services | 104 |